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. 2002 Jan;64(1):67-9.
doi: 10.1292/jvms.64.67.

Protective effect of Clostridium septicum alpha-toxoid vaccine against challenge with spores in guinea pigs

Katsuhiko Amimoto  1 , Toshiaki Ohgitani, Osamu Sasaki, Eiji Oishi, Shigeji Katayama, Makoto Isogai, Sotoyuki Ota
Affiliations
Free article

Protective effect of Clostridium septicum alpha-toxoid vaccine against challenge with spores in guinea pigs

Katsuhiko Amimoto et al. J Vet Med Sci. 2002 Jan.
Free article

Abstract

The protective effect of an alpha-toxoid vaccine of Clostridium septicum purified alpha-toxin was investigated in guinea pigs. Purified alpha-toxin was treated with formalin to make toxoid, and alpha-toxoid vaccine was prepared by mixing alpha-toxoid (4 to 64 microg/dose) with an aluminum phosphate gel as adjuvant. Guinea pigs were immunized twice with different doses of alpha-toxoid vaccine, and challenged with spores of C. septicum. The guinea pigs surviving after challenge had been immunized with 8 microg/dose or more of alpha-toxoid. All these animals produced titers of 20 units or higher of antitoxin at the challenge. The results suggest that C. septicum alpha-toxin plays an important role in protection against challenge with spores in guinea pigs.

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