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Clinical Trial
. 2001 Oct:84 Suppl 2:S576-81.

Treatment of painful osteoarthritis of the knee with hyaluronic acid. Results of a multicenter Asian study

N Bunyaratavej  1 , K M Chan, N Subramanian
Affiliations
  • PMID: 11853284
Clinical Trial

Treatment of painful osteoarthritis of the knee with hyaluronic acid. Results of a multicenter Asian study

N Bunyaratavej et al. J Med Assoc Thai. 2001 Oct.

Abstract

Hyaluronic acid is a component of synovial fluid, in osteoarthritis (OA) and shows a change of property of hyaluronic acid especially its viscoelasticity causing degradation of the cartilage. Injection of hyaluronic acid into OA of the knee (Hyalgan 2 ml/wk for 4 doses) in international multicentres gave dramatic responses: decreased pain, increased mobility of the joint after 49 days of injections compared to a placebo (2 ml of normal saline) p<0.01.

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