Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Feb;4(1):17-27.
doi: 10.1007/s11908-002-0063-6.

The Oxazolidinones

Affiliations

The Oxazolidinones

Gerald A. Evans. Curr Infect Dis Rep. 2002 Feb.

Abstract

The need for effective antibiotics to manage the ever increasing frequency of antibiotic-resistant gram-positive infections in much of the developed world has led to the clinical development of the first oxazolidinone antibiotic, linezolid. Linezolid possesses bacteriostatic activity against both antibiotic-susceptible and resistant strains of staphylococci, enterococci, and streptococci of relevance to human infection. Clinical trials have confirmed its effectiveness in the treatment of serious infections of skin and soft tissue and the lower respiratory tract. Linezolid has also provided improved outcomes in the treatment of serious vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus infections in a compassionate use program. Emergence of linezolid-resistant gram-positive cocci during clinical use has recently been described, suggesting that its present role in therapy should be reserved for the treatment of antibiotic-resistant gram-positive infections.

PubMed Disclaimer

References

    1. Antimicrob Agents Chemother. 2001 Jul;45(7):2154-6 - PubMed
    1. Clin Infect Dis. 2001 Sep 15;33 Suppl 3:S233-7 - PubMed
    1. J Biol Chem. 2001 Oct 5;276(40):37199-205 - PubMed
    1. Lancet. 2001 Jul 21;358(9277):207-8 - PubMed
    1. Lancet. 2001 Apr 14;357(9263):1179 - PubMed

LinkOut - more resources