Review
doi: 10.1016/s1357-2725(01)00131-5.
DNA polymerase beta
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- PMID: 11854030
- DOI: 10.1016/s1357-2725(01)00131-5
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Review
DNA polymerase beta
Int J Biochem Cell Biol.
2002 Apr.
Abstract
Mammalian DNA polymerase beta(beta-pol) is a single polypeptide chain enzyme of 39kDa. beta-pol has enzymatic activities appropriate for roles in base excision repair and other DNA metabolism events involving gap-filling DNA synthesis. Many crystal structures of beta-pol complexed with dNTP and DNA substrates have been solved, and mouse fibroblast cell lines deleted in the beta-pol gene have been examined. These approaches have enhanced our understanding of structural and functional aspects of beta-pol's role in protecting genomic DNA.
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