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Review
. 2002 Feb;109(4):447-9.
doi: 10.1172/JCI15094.

Genetic models: clues for understanding the pathogenesis of idiopathic nephrotic syndrome

Corinne Antignac  1
Affiliations
Review

Genetic models: clues for understanding the pathogenesis of idiopathic nephrotic syndrome

Corinne Antignac. J Clin Invest. 2002 Feb.
No abstract available

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Figures

Figure 1
Figure 1
Mechanisms underlying idiopathic NS. In both its steroid-sensitive and its steroid-insensitive form, this condition can apparently arise through a T cell dysfunction that leads to the synthesis of a still-unidentified circulating factor that compromises the glomerular permeability barrier. By contrast, in a subset of steroid-resistant NS, the disease is due to a primary defect in the glomerular filtration filter. The potential interactions between this immune defect and altered structural properties of the glomerular epithelium remain highly speculative.
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