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Comment
. 2002 Feb 19;99(4):1752-4.
doi: 10.1073/pnas.062034799.

New insights into unwrapping DNA from the nucleosome from a single-molecule optical tweezers method

Jeffrey J Hayes  1 , Jeffrey C Hansen
Affiliations
Comment

New insights into unwrapping DNA from the nucleosome from a single-molecule optical tweezers method

Jeffrey J Hayes et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Unwrapping histone–DNA contacts within the nucleosome. Cartoon with core histones H2A, H2B, H3, and H4 shown as blue, green, yellow, and magenta, respectively, with α-helices as columns. DNA in the nucleosome is shown (ribbons, ref. 9) with approximate distance in base pairs from the dyad (center, bold vertical line) of the nucleosome indicated. Note that only the top four polypeptides and top turn of DNA in the top half of the symmetrical structure are shown for clarity. A small amount of H3 (light yellow) emanating from the bottom half of the structure is shown as well. The H3:H3 and H4:H2B interfaces between dimers are indicated as vertical and angled bold lines, respectively. Gray dashed line indicates a possible path of DNA after exiting the nucleosome. The stretches of DNA unwrapped in the first and second transitions in the study by Brower-Toland et al. are indicated by the light and dark gray curved arrows, respectively. The figure is based on refs. and .
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Comment on

References

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    1. Wolffe A P. Chromatin Structure and Function. 3rd Ed. San Diego: Academic; 1998.
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    1. Brower-Toland B D, Smith C L, Yeh R C, Lis J T, Peterson C L, Wang M D. Proc Natl Acad Sci USA. 2002;99:1960–1965. - PMC - PubMed
    1. Eickbusch T H, Moudrianakis E N. Biochemistry. 1978;17:4955–4967. - PubMed

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