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Comment
. 2002 Feb 19;99(4):1755-7.
doi: 10.1073/pnas.062039699.

Will embryonic stem cells be a useful source of dopamine neurons for transplant into patients with Parkinson's disease?

Curt R Freed  1
Affiliations
Comment

Will embryonic stem cells be a useful source of dopamine neurons for transplant into patients with Parkinson's disease?

Curt R Freed. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Human fetal dopamine neuron in putamen of Parkinson's patient dying 8 years after cell transplantation. The cell is immunostained for tyrosine hydroxylase and has multiple processes growing out from the cell body to specifically reinnervate the surrounding brain region. Other staining methods used on other transplanted cells in the same patient revealed the neuromelanin pigment particles typical of mature substantia nigra dopamine neurons. Immunosuppression was used for the first year after transplant, but not for the subsequent 7 years. If human ES cells can be differentiated to a phenotype identical to fetal substantia nigra dopamine neurons, those cells should have the same stable survival seen in this patient's transplant. (Magnification: ×400.)
See this image and copyright information in PMC

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