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Meta-Analysis
. 2001 Dec;7(6):801-4.
doi: 10.3748/wjg.v7.i6.801.

Association of H. pylori infection with gastric carcinoma: a Meta analysis

F B Xue  1 , Y Y Xu, Y Wan, B R Pan, J Ren, D M Fan
Affiliations
Meta-Analysis

Association of H. pylori infection with gastric carcinoma: a Meta analysis

F B Xue et al. World J Gastroenterol. 2001 Dec.

Abstract

Aim: To follow the principles of evidence based medicine to reach the integrated results of these studies.

Methods: Twenty-one papers of case-control studies were selected, including 11 on gastric cancer,7 on precancerous lesion of stomach and 3 on lymphoma of stomach. Meta analysis was used to sum up the odds ratios (OR) of these studies.

Results: H. pylori vs gastric cancer (intestinal and diffuse type): the odds ratio from the fixed effect model is 3.0016 (95% CI: 2.4197-3.7234, P<0.001). H. pylori vs precancerous lesion of stomach: a random effect model was used to calculate the summary odds ratio and its value is 2.5635 (95% CI: 1.8477-3.5566, P<0.01). H. pylori vs lymphoma of stomach: though the quantity of literature is too small to make Meta analysis, the data of these 3 studies show that lymphoma of stomach is highly associated with H. pylori infections.

Conclusion: Since it had been revealed that H. pylori infection pre-exists in gastric carcinoma and precancerous lesions, the results of Meta analysis present a strong evidence to support the conclusion that H. pylori infection is a risk factor for gastric carcinoma.

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Figures

Figure 1
Figure 1
Odds ratios and summary odds ratio with 95%CI of 11 case-control studies.
Figure 2
Figure 2
Odds ratios and summary odds ratio with 95%CI of 7 case-control studies.
Figure 3
Figure 3
Odds ratios with 95%CI of 3 case-control studies.
See this image and copyright information in PMC

References

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    1. Wang JY. Recent development of studies on relation between H. pylori infection and gastric cancer. Huaren Xiaohua Zazhi. 1998;6:829–830.

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