Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2001 Dec;7(6):801-4.
doi: 10.3748/wjg.v7.i6.801.

Association of H. pylori infection with gastric carcinoma: a Meta analysis

Affiliations
Meta-Analysis

Association of H. pylori infection with gastric carcinoma: a Meta analysis

F B Xue et al. World J Gastroenterol. 2001 Dec.

Abstract

Aim: To follow the principles of evidence based medicine to reach the integrated results of these studies.

Methods: Twenty-one papers of case-control studies were selected, including 11 on gastric cancer,7 on precancerous lesion of stomach and 3 on lymphoma of stomach. Meta analysis was used to sum up the odds ratios (OR) of these studies.

Results: H. pylori vs gastric cancer (intestinal and diffuse type): the odds ratio from the fixed effect model is 3.0016 (95% CI: 2.4197-3.7234, P<0.001). H. pylori vs precancerous lesion of stomach: a random effect model was used to calculate the summary odds ratio and its value is 2.5635 (95% CI: 1.8477-3.5566, P<0.01). H. pylori vs lymphoma of stomach: though the quantity of literature is too small to make Meta analysis, the data of these 3 studies show that lymphoma of stomach is highly associated with H. pylori infections.

Conclusion: Since it had been revealed that H. pylori infection pre-exists in gastric carcinoma and precancerous lesions, the results of Meta analysis present a strong evidence to support the conclusion that H. pylori infection is a risk factor for gastric carcinoma.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Odds ratios and summary odds ratio with 95%CI of 11 case-control studies.
Figure 2
Figure 2
Odds ratios and summary odds ratio with 95%CI of 7 case-control studies.
Figure 3
Figure 3
Odds ratios with 95%CI of 3 case-control studies.

Similar articles

Cited by

References

    1. Zhao ZQ. Association of H. pylori infection with gastroduodenal diseases. Tiedao Yixue. 1998;26:212–214.
    1. Gao XH, Pan BR. Helicobacter pylori infection and gastric cancer. Xin Xiaohuabingxue Zazhi. 1995;3:223–224.
    1. Zhang WD, Xu KQ. Progress in research of the role of Helicobacter pylori in the process of occurrence of gastric cancer. Xin Xiaohuabingxue Zazhi. 1997;5(Suppl 6):9–11.
    1. Zu Y, Shu J, Yang CM, Zhong ZF, Dai HY, Wang X, Qin GM. Study on relation between H. pylori infection and risk of gastric cancer. Huaren Xiaohua Zazhi. 1998;6:367–368.
    1. Wang JY. Recent development of studies on relation between H. pylori infection and gastric cancer. Huaren Xiaohua Zazhi. 1998;6:829–830.

Publication types