Rapid methods for bioavailability determination utilizing urinary excretion data

Abstract

Two equations were developed which enable urinary excretion data to be utilized for estimating drug bioavailability within 12 hr-starting between one and two half-lives of the drug, depending upon the relative rates of absorption, distribution, and elimination. Both equations were examined using simulated data for both the one- and two-compartment open models. One equation was tested using literature data with excellent results.