Review
doi: 10.1016/s0896-6273(02)00592-5.
Sodium channels: grit, determination, and persistence
Affiliations
- PMID: 11856523
- DOI: 10.1016/s0896-6273(02)00592-5
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Review
Sodium channels: grit, determination, and persistence
Neuron.
.
Free article
Abstract
Persistent sodium channel activity modulates neuronal gain in a neurotransmitter-dependent fashion. Previous studies have suggested that persistent and spike-related sodium channel activities are mediated by separate species. In this issue of Neuron, Taddese and Bean (2002) show that a single channel population is sufficient to explain both gating behaviors. A simple allosteric model is provided that can explain the results.
Comment on
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Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons.Neuron. 2002 Feb 14;33(4):587-600. doi: 10.1016/s0896-6273(02)00574-3. Neuron. 2002. PMID: 11856532
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