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Review
. 2002 Feb 14;33(4):492-4.
doi: 10.1016/s0896-6273(02)00592-5.

Sodium channels: grit, determination, and persistence

John R Huguenard  1
Affiliations
Free article
Review

Sodium channels: grit, determination, and persistence

John R Huguenard. Neuron. .
Free article

Abstract

Persistent sodium channel activity modulates neuronal gain in a neurotransmitter-dependent fashion. Previous studies have suggested that persistent and spike-related sodium channel activities are mediated by separate species. In this issue of Neuron, Taddese and Bean (2002) show that a single channel population is sufficient to explain both gating behaviors. A simple allosteric model is provided that can explain the results.

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