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. 2002 Feb;65(2):210-4.
doi: 10.1021/np0104020.

Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata

Deniz Tasdemir  1 , Gina C Mangalindan, Gisela P Concepción, Sheryl M Verbitski, Sridhar Rabindran, Miriam Miranda, Michael Greenstein, John N A Hooper, Mary Kay Harper, Chris M Ireland
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Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata

Deniz Tasdemir et al. J Nat Prod. 2002 Feb.

Abstract

Two new isomalabaricane triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A-D (3-6), (-)-stellettin E (7), and rhabdastrellic acid-A (8) were also isolated and characterized. Stellettin B (4) and (-)-stellettin E (7) showed selective cytotoxicity toward p21(WAF1/Cip1)-deficient human colon tumor (HCT-116) cells with IC(50) values of 0.043 and 0.039 microM, respectively.

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