Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Feb 23;324(7335):474-6.
doi: 10.1136/bmj.324.7335.474.

Does animal experimentation inform human healthcare? Observations from a systematic review of international animal experiments on fluid resuscitation

Affiliations

Does animal experimentation inform human healthcare? Observations from a systematic review of international animal experiments on fluid resuscitation

Ian Roberts et al. BMJ. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Meta-analysis of 16 randomised controlled trials of fluid resuscitation in rats with uncontrolled haemorrhage by tail resection. *Capone11 reported two trials
Figure 2
Figure 2
Trial size and smallest absolute risk reduction detectable

Comment in

References

    1. Croce P. Vivisection or science? An investigation into testing drugs and safeguarding health. London: Zed Books; 1999.
    1. Roberts I, Evans A, Bunn F, Kwan I, Crowhurst E. Normalising the blood pressure in bleeding trauma patients may be harmful. Lancet. 2001;357:385–387. - PubMed
    1. Bilynskyj MC, Errington ML, Velasco IT, Silva R. Effect of hypertonic sodium chloride (7.5%) on uncontrolled hemorrhage in rats and its interaction with different anesthetic procedures. Circulatory Shock. 1992;36:68–73. - PubMed
    1. Gross D, Landau EH, Klin B, Krausz MM. Quantitative measurement of bleeding following hypertonic saline therapy in ‘uncontrolled’ hemorrhagic shock. J Trauma. 1989;29:79–83. - PubMed
    1. Krausz MM, Kablan M, Rabinovici R, Klin B, Sherman Y, Gross D. Effect of injured vessel size on bleeding following hypertonic saline infusion in uncontrolled hemorrhagic shock in anesthetised rats. Circulatory Shock. 1991;35:9–13. - PubMed

Publication types