[Relationship between glutathione S-transferase M1, T1 genotype and susceptibility to gastric cancer]

Abstract

Objective: The objective of this study was to examine the association between glutathione s-transferase M1, T1 genotype and the risk of gastric cancer.

Methods: A case-control study was carried out and polymerase chain reaction (PCR) technique was used to identify GST M1, GST T1 genotype in 95 cases of primary gastric cancer and 94 controls.

Results: The frequency of GST M1 null genotype was 63.16% and 45.74%, respectively in gastric cancer cases and control group, with statistically significant difference (chi(2) = 5.75, P = 0.0165). GST M1 null genotype correlated with the susceptibility to gastric cancer (OR = 2.03, 95% CI of OR = 1.09 - 3.80). The risk for gastric cancer in those with GST M1 null and GST T1 non-null genotype was significantly higher than that in those with GST M1 non-null and GST T1 null genotype, with an OR of 2.91 and 95% CI of ORs 1.09 - 7.89. The risk for gastric cancer in those smoking with GST M1 null genotype increased significantly (OR = 8.06, 95% CI of OR = 2.83 - 23.67).

Conclusion: GST M1 null genotype was associated with the risk for gastric cancer.