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. 2002 Mar 6;124(9):1848-9.
doi: 10.1021/ja016784d.

SCMTR: a chloride-selective, membrane-anchored peptide channel that exhibits voltage gating

Paul H Schlesinger  1 , Riccardo Ferdani, Jun Liu, Jolanta Pajewska, Robert Pajewski, Mitsuyoshi Saito, Hossein Shabany, George W Gokel
Affiliations

SCMTR: a chloride-selective, membrane-anchored peptide channel that exhibits voltage gating

Paul H Schlesinger et al. J Am Chem Soc. .

Abstract

The design, synthesis, and characterization of a synthetic chloride membrane transporter, SCMTR (synthetic chloride membrane transporter, "scimitar"), are presented. The compound [CH3(CH2)17]2NCOCH2OCH2CO-GGGPGGG-OBzl inserts rapidly into liposomes and planar lipid bilayers. SCMTR has a 1.3 +/- 0.01 nS chloride diffusion pathway (>10:1 Cl/K selectivity). Evidence was also obtained for voltage gating behavior.

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