[Histocompatibility HLA system of man. Considerations in the light of current concepts. V. sHLA-I in patient's body fluids]

Abstract

The retrospective estimation of concentrations of soluble HLA class I antigens (sHLA-I) in blood serum and in other body fluids of patients was executed. The physiological concentration of sHLA-I is significantly upregulated in various diseases and during inflammation, and following organ transplantation. This suggested that sHLA-I might serve as a marker of pathological changes. Observed differences in sHLA-I levels among different diseases could reflect variability in genetic factors, pathophysiology or disease activity. The authors show on usefulness of obtained results to comparative analysis of particular HLA class I allospecificities concentrations characteristic for some diseases, for example HLA-Cw7 in patients with SNHL, or HLA-B27 in zzsk. Estimation of sHLA-I concentrations in blood sera of patients could represents a good diagnostic and prognostic marker in monitoring of course disease and its activity.