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. 1975 Oct 30;257(5529):764-7.
doi: 10.1038/257764a0.

Regulation of cell cycle stage-specific transcription of histone genes from chromatin by non-histone chromosomal proteins

G Stein, W Park, C Thrall, R Mans, J Stein

Regulation of cell cycle stage-specific transcription of histone genes from chromatin by non-histone chromosomal proteins

G Stein et al. Nature. .

Abstract

RNA transcripts from chromatin of S phase but not G1 cells contain histone-specific sequences. Chromatin reconstituted with S phase non-histone chromosomal proteins transcribes histone messenger RNA sequences whereas chromatin reconstituted with G1 non-histone proteins does not. These results suggest that transcription of histone genes is regulated during the cell cycle and that non-histone proteins have a key role in this regulation.

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