Review
doi: 10.1016/s0952-7915(02)00316-3.
NKT cells - conductors of tumor immunity?
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- PMID: 11869887
- DOI: 10.1016/s0952-7915(02)00316-3
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Review
NKT cells - conductors of tumor immunity?
Curr Opin Immunol.
2002 Apr.
Abstract
NKT cells are key players in the regulation of antitumor immunity, particularly in experimental models of tumor immunotherapy, such as IL-12 or alpha-galactosylceramide administration. They may also operate in natural antitumor immunity. NKT cells are best known for their immunosuppressive functions; however, NKT cells interact with a range of other cell types (particularly dendritic cells and NK cells) and the outcome of NKT-cell stimulation depends on these and on the cytokine/co-stimulatory milieu.
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