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. 2002 Feb 12;86(4):546-51.
doi: 10.1038/sj.bjc.6600132.

Dendritic cell density and activation status in human breast cancer -- CD1a, CMRF-44, CMRF-56 and CD-83 expression

B J Coventry  1 , P-L Lee, D Gibbs, D N J Hart
Affiliations
Free PMC article

Dendritic cell density and activation status in human breast cancer -- CD1a, CMRF-44, CMRF-56 and CD-83 expression

B J Coventry et al. Br J Cancer. .
Free PMC article

Abstract

Low CD1a-positive putative dendritic cell numbers in human breast cancer has recently been described and may explain the apparent 'poor immunogenicity' previously reported in breast cancer. Little attention has been given to dendritic cell activation within the tumour microenvironment, which is another reason why the in-situ immune response may be severely deficient. We have therefore examined CD1a expression as a marker for dendritic cells, together with CMRF-44 and -56 as markers of dendritic cell activation status, in 40 human breast cancers. The results demonstrate few or no CD1a-positive putative dendritic cells and minimal or no expression of the dendritic cell activation markers. Both dendritic cell number and dendritic cell activation appear substantially deficient in human breast cancers, regardless of tumour histological grade.

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Figures

Figure 1
Figure 1
CMRF-44 staining in human breast cancer (Part 1) (×200).
Figure 2
Figure 2
CMRF-56 positive cells in human breast cancer (Part 1) (×200).
Figure 3
Figure 3
CD1a positive cells in human breast cancer (Part 1) (×200).
See this image and copyright information in PMC

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