doi: 10.1038/ni760.
Epub 2002 Jan 28.
Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4
Affiliations
- PMID: 11875462
- DOI: 10.1038/ni760
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Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4
Nat Immunol.
2002 Mar.
Abstract
Immunoglobulin-like transcript 3 (ILT3) and ILT4 belong to a family of inhibitory receptors expressed by human monocytes and dendritic cells. We show here that CD8+CD28(-) alloantigen-specific T suppressor (TS) cells induce the up-regulation of ILT3 and ILT4 on monocytes and dendritic cells, rendering these antigen-presenting cells (APCs) tolerogenic. Tolerogenic APCs show reduced expression of costimulatory molecules and induce antigen-specific unresponsiveness in CD4+ T helper cells. Studies of human heart transplant recipients showed that rejection-free patients have circulating TS cells, which induce the up-regulation of ILT3 and ILT4 in donor APCs. These findings demonstrate an important mechanism of immune regulation.
Comment in
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T(S) cells and immune tolerance induction: a regulatory renaissance?Nat Immunol. 2002 Mar;3(3):215-7. doi: 10.1038/ni0302-215. Nat Immunol. 2002. PMID: 11875459 No abstract available.
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