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. 2002 Apr;70(4):985-93.
doi: 10.1086/339815. Epub 2002 Mar 1.

Age at onset in two common neurodegenerative diseases is genetically controlled

Yi-Ju Li  1 , William K Scott, Dale J Hedges, Fengyu Zhang, P Craig Gaskell, Martha A Nance, Ray L Watts, Jean P Hubble, William C Koller, Rajesh Pahwa, Matthew B Stern, Bradley C Hiner, Joseph Jankovic, Fred A Allen Jr, Christopher G Goetz, Frank Mastaglia, Jeffrey M Stajich, Rachel A Gibson, Lefkos T Middleton, Ann M Saunders, Burton L Scott, Gary W Small, Kristin K Nicodemus, Allison D Reed, Donald E Schmechel, Kathleen A Welsh-Bohmer, P Michael Conneally, Allen D Roses, John R Gilbert, Jeffery M Vance, Jonathan L Haines, Margaret A Pericak-Vance
Affiliations

Age at onset in two common neurodegenerative diseases is genetically controlled

Yi-Ju Li et al. Am J Hum Genet. 2002 Apr.

Abstract

To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n=449) and Parkinson disease (PD; n=174). Heritabilities between 40%--60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD = 3.28) was confirmed. In addition, evidence for AAO linkage on chromosomes 6 and 10 was identified independently in both the AD and PD data sets. Subsequent unified analyses of these regions identified a single peak on chromosome 10q between D10S1239 and D10S1237, with a maximum LOD score of 2.62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases.

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Figures

Figure 1
Figure 1
Results of chromosome 10 multipoint linkage analyses. Marker distances were based on sex-averaged Kosambi centimorgans according to Map-O-Mat.
Figure 2
Figure 2
Map positions of reported linkage results for the risk and AAO genes on chromosome 10q.
See this image and copyright information in PMC

References

Electronic-Database Information

    1. Online Mendelian Inheritance in Man (OMIM), http://www.ncbi.nlm.nih.gov/Omim/ (for AD [MIM 104300] and PD [MIM 168600])
    1. Map-O-Mat, http://compgen.rutgers.edu/mapomat/

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