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Review
. 2002 Feb;127(2):193-8.
doi: 10.1046/j.1365-2249.2002.01792.x.

Unlocking the immunological mechanisms of orbital inflammation in thyroid eye disease

M Ludgate  1 , G Baker
Affiliations
Review

Unlocking the immunological mechanisms of orbital inflammation in thyroid eye disease

M Ludgate et al. Clin Exp Immunol. 2002 Feb.
No abstract available

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Figures

Fig. 1
Fig. 1
Summary of the steps involved in the initiation of TED. (1) T cells recognize TSHR on orbital fibroblasts. (2) Activated mast cells aid fibroblast activation, stimulate a Th2 response and (3) stimulate TSAB production. (4) Fibroblast activation results in the production of proinflammatory mediators and adhesion molecules with the preadipocyte fraction undergoing differentiation and increasing TSHR expression that heightens TSH/TSAB sensitivity. The resultant inflammation and adipogenesis produce the clinical manifestations of TED.
See this image and copyright information in PMC

References

    1. Weetman AP, McGregor AM. Autoimmune Thyroid Disease; Further Developments In Our Understanding. Endocr Revs. 1994;15:788–830. - PubMed
    1. Rees Smith B, McLachlan S, Furmaniak J. Autoantibodies to the Thyrotropin Receptor. Endocr Revs. 1998;9:106–20. - PubMed
    1. Paschke R, Ludgate M. The Thyrotropin Receptor in Thyroid Disease. N Engl J Med. 1997;337:1675–81. - PubMed
    1. Perros P, Kendall-Taylor P. Thyroid-Associated Ophthalmopathy – Pathogenesis and clinical management. Baillieres Clin Endocrinol Metab. 1995;9:115–35. - PubMed
    1. Heufelder AE, Weetman AP, Ludgate M, Bahn RS. Pathogenesis of Graves’ ophthalmopathy. In: Prummel MF, Wiersinga WM, Mourits MP, editors. Recent Developments in Graves’ Ophthalmopathy. Dordrecht: Kluwer Academic Publishers; 2000. pp. 15–37.

MeSH terms