[The effects of rapid fluid replacement on the hemodynamics of scalded shock dogs with delayed resuscitation]

Abstract

Objective: To investigate the effects of rapid fluid replacement on the hemodynamics of scalded shock dogs with delayed resuscitation and to explore the protocol for the correction of postburn shock in case of delayed resuscitation.

Methods: Mongrel dogs inflicted with 40% TBSA III degree scalding were employed in the study. Twenty -- four dogs were randomly divided into 3 groups, i.e. thermal injury control group (C), delayed even fluid infusion group (E) and delayed rapid fluid infusion group (R). The femoral arterial pressure (FAP), pulmonary arterial pressure (PAP), pulmonary vascular resistance (PVP) and systemic vascular resistance (SVR) were monitored before and 2, 6, 8, 12, 24, 36 and 48 hours after injury.

Results: (1)All The dogs in C group died within 36 postburn hours (PBHs), while those in E and R groups survived more than 48 PBHs. (2) FAP and CO in all the dogs decreased obviously postburn while SVR increased evidently. After fluid infusion, FAP and CO bounced back while SVR decreased, especially in R group. (3) PAP, PAWP, CVP and PVR recovered rapidly but within normal range in R group.

Conclusion: Rapid fluid resuscitation was beneficial and feasible for the correction of burn shock due to delayed resuscitation.