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Review
. 2002 Mar;109(5):565-9.
doi: 10.1172/JCI15209.

Intrinsic and innate defenses in the lung: intersection of pathways regulating lung morphogenesis, host defense, and repair

Jeffrey A Whitsett  1
Affiliations
Review

Intrinsic and innate defenses in the lung: intersection of pathways regulating lung morphogenesis, host defense, and repair

Jeffrey A Whitsett. J Clin Invest. 2002 Mar.
No abstract available

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Figures

Figure 1
Figure 1
The sterility of the respiratory tract is maintained by the concerted actions of the epithelial barrier, innate defense molecules, and responses of both the epithelium and professional phagocytes that remove pathogens and their products from the lung.
Figure 2
Figure 2
Transcription proteins, including TTF-1, HNF, and GATA family members, mediate lung morphogenesis, epithelial cell differentiation, and gene expression, creating the diverse cells of the epithelial barrier and regulating intrinsic and innate host defense responses.
Figure 3
Figure 3
FGF signaling in formation of the trachea and lung has been conserved from insects to vertebrates. FGFs influence proliferation, migration, and differentiation of respiratory epithelial cells, surfactant protein, and other host defense polypeptides that, in turn, orchestrate cytokine expression and the function of professional phagocytic cells mediating innate and acquired host defenses.
Figure 4
Figure 4
Formation and function of the lung are mediated by intrinsic and innate defense systems that are orchestrated by ancient transcriptional and signaling pathways that have allowed adaptation of vertebrates to air breathing.
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