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Comment
. 2002 Mar 4;195(5):F19-23.
doi: 10.1084/jem.20020073.

Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity

Albert Bendelac  1 , Ruslan Medzhitov
Affiliations
Comment

Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity

Albert Bendelac et al. J Exp Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Adjuvant pathways. Various classes of microbial or nonmicrobial adjuvants are specifically recognized by invariant receptors such as TLRs expressed by DCs, soluble complement factors, or even invariant TCRs expressed by specialized subsets of CD1d-restricted NKT αβ T cells and γδ T cells. The resulting adjuvant cascades generally lower the antigen concentration required to trigger the adaptive B or T cell responses, and/or provide cytokines which favor Th1 or Th2 differentiation.
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