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. 1975 Aug 21;43(2):169-73.
doi: 10.1007/BF00421020.

Cholinergic modulation of an opposed effect of d-amphetamine and methylphenidate on the rearing response

K S Bryan, G Ellison

Cholinergic modulation of an opposed effect of d-amphetamine and methylphenidate on the rearing response

K S Bryan et al. Psychopharmacologia. .

Abstract

Rats given d-amphetamine (1 mg/kg) engage in frequent, short-duration rearing responses, whereas rats given methylphenidate (1 mg/kg) make less frequent, long-duration responses. The effects on this behavior of mixing d-amphetamine or methylphenidate with scopolamine or physostigmine suggest that this opposed action on rearing response duration is related to cholinergic-catecholaminergic balance. The anticholinergic agent scopolamine produces changes in rearing response duration similar to those produced by d-amphetamine, while the cholinergic agent physostigmine lengthens response duration and further potentiates this effect of methylphenidate.

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