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. 2002 Apr 1;34(7):1002-7.
doi: 10.1086/339448. Epub 2002 Feb 27.

Increased survival of persons with tuberculosis and human immunodeficiency virus infection, 1991--2000

Michael K Leonard  1 , Nina Larsen, Henning Drechsler, Henry Blumberg, Jeffrey L Lennox, Martha Arrellano, Jennifer Filip, C Robert Horsburgh Jr
Affiliations

Increased survival of persons with tuberculosis and human immunodeficiency virus infection, 1991--2000

Michael K Leonard et al. Clin Infect Dis. .

Abstract

To determine factors associated with the occurrence of human immunodeficiency virus (HIV) infection and tuberculosis (TB) disease (HIV-TB) and the associated survival rate, we analyzed patients with HIV-TB at Grady Memorial Hospital, Atlanta, Georgia, from 1991 through 2000. Overall, 644 patients with HIV-TB were seen. The number of HIV-TB cases per year was highest in 1992 (102 cases) and declined to 39 cases in 2000. Over time, patients were more likely to be enrolled in the HIV outpatient clinic (P<.01), but, in 1997, only 21 (51%) of 41 patients were enrolled in HIV-infection care programs and only 9 (22%) of 41 received HAART. The 1-year survival rate for patients with HIV-TB was 58% in 1991, 81% in 1994, and 83% in 1997 (P<.001). The increase in survival for patients with HIV-TB between 1991 and 1994 was likely due to improved TB and HIV therapy. More effective strategies for enrolling and maintaining HIV-TB patients in HIV-infection care programs could further increase survival.

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