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. 2002 Jan;71(2):171-3.
doi: 10.1023/a:1013828710301.

Selective axillary surgery in breast cancer patients based on positron emission tomography with 18F-fluoro-2-deoxy-D-glucose: not yet!

Ulrich Guller  1 , Egbert U Nitzsche, Udo Schirp, Carsten T Viehl, Joachim Torhorst, Holger Moch, Igor Langer, Walter R Marti, Daniel Oertli, Felix Harder, Markus Zuber
Affiliations

Selective axillary surgery in breast cancer patients based on positron emission tomography with 18F-fluoro-2-deoxy-D-glucose: not yet!

Ulrich Guller et al. Breast Cancer Res Treat. 2002 Jan.

Abstract

We prospectively evaluated 31 patients with invasive breast cancer. Preoperative positron emission tomography (PET) with 18F-fluoro-2-deoxy-D-glucose (18F-FDG) for detection of axillary lymph node metastases was compared with the histopathologic status of the sentinel lymph node (SLN). Sensitivity of PET imaging was 43%, specificity and negative predictive value were 94 and 67%, respectively. The smallest metastasis detected by PET measured 3 mm in diameter. The results of this study suggest that detection of small axillary lymph node metastases is limited by the currently achievable spatial resolution of PET imaging. Selective axillary surgery in breast cancer patients based on 18F-FDG PET is yet not possible.

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