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. 2000 Feb 15;3(1):50-52.

Posttraumatic expression of MHC II molecules: an experimental and clinical study

Haichen Sun  1 , Xuehao Wu, Xiaoming Qian, Xiaoping Qi, Wenjie Tang, Jianqiang Xu, Jieshou Li
Affiliations
  • PMID: 11882268

Posttraumatic expression of MHC II molecules: an experimental and clinical study

Haichen Sun et al. Chin J Traumatol. .

Abstract

OBJECTIVE: To evaluate the role of MHC II expression in posttrauma immune disturbances and infections. METHODS: In experimental study, peritoneal macrophages were harvested from traumatized mice and treated with GM-CSF, Ia molecules were determined by flow cytometry. In 24 trauma patients, monocyte HLA-DR expression was measured by APAAP technique. RESULTS: Marked inhibition of MHC II molecule expression was found in both traumatized mice and patients. In traumatic patients with infection, the inhibition was more severe. Treatment with GM-CSF in mice partially restored the Ia expression. CONCLUSIONS: Inhibition of MHC II molecules plays an important role in postrauma immune disturbances. There is a close relationship between HLA-DR inhibition and clinical infections.

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