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. 1975 Nov 7;190(4214):584-6.
doi: 10.1126/science.1188358.

Guanidinium-CsCl density gradients for isopycnic analysis of nucleic acids

V Enea, N D Zinder

Guanidinium-CsCl density gradients for isopycnic analysis of nucleic acids

V Enea et al. Science. .

Abstract

The addition of guanidinium chloride to CsCl gradients lowers the apparent density of RNA, DNA, and hybrid polymers in such a way that all three can be banded, fractionated, and analyzed in one gradient with essentially no damage to their chemical integrity or to their biological activity.

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