Review
Recombinant yeast as a vaccine vector for the induction of cytotoxic T-lymphocyte responses
Affiliations
- PMID: 11883693
Item in Clipboard
Review
Recombinant yeast as a vaccine vector for the induction of cytotoxic T-lymphocyte responses
Curr Opin Mol Ther.
2002 Feb.
Abstract
There is currently a need to develop safe and effective vaccines for the induction of cellular, in particular cytotoxic T-lymphocyte-mediated, protective immune responses. This review focuses on the challenges presented by such an endeavor, current strategies for the induction of such responses, and the relatively new idea that recombinant yeast may represent an ideal vaccine vector for the induction of cellular immune responses.
Similar articles
-
A recombinant live attenuated measles vaccine vector primes effective HLA-A0201-restricted cytotoxic T lymphocytes and broadly neutralizing antibodies against HIV-1 conserved epitopes.Vaccine. 2005 Aug 22;23(36):4463-72. doi: 10.1016/j.vaccine.2005.04.024. Vaccine. 2005. PMID: 15993518
-
Virus-like particles as HIV-1 vaccines.Rev Med Virol. 2005 Mar-Apr;15(2):75-88. doi: 10.1002/rmv.449. Rev Med Virol. 2005. PMID: 15484204 Review.
-
[Novel vaccines against M. tuberculosis].Kekkaku. 2006 Dec;81(12):745-51. Kekkaku. 2006. PMID: 17240920 Review. Japanese.
-
Recombinant fowlpox virus elicits transient cytotoxic T cell responses due to suboptimal innate recognition and recruitment of T cell help.Vaccine. 2008 Jul 4;26(29-30):3566-73. doi: 10.1016/j.vaccine.2008.05.015. Epub 2008 May 27. Vaccine. 2008. PMID: 18541346
-
Hepatitis B surface antigen vector delivers protective cytotoxic T-lymphocyte responses to disease-relevant foreign epitopes.J Virol. 2006 Apr;80(8):3975-84. doi: 10.1128/JVI.80.8.3975-3984.2006. J Virol. 2006. PMID: 16571814 Free PMC article.
Cited by
-
In vivo phage display to identify M cell-targeting ligands.Pharm Res. 2004 Apr;21(4):695-705. doi: 10.1023/b:pham.0000022418.80506.9a. Pharm Res. 2004. PMID: 15139528
-
Yeast display platform technology to prepare oral vaccine against lethal H7N9 virus challenge in mice.Microb Cell Fact. 2020 Mar 2;19(1):53. doi: 10.1186/s12934-020-01316-1. Microb Cell Fact. 2020. PMID: 32122351 Free PMC article.
-
Vaccination with a recombinant Saccharomyces cerevisiae expressing a tumor antigen breaks immune tolerance and elicits therapeutic antitumor responses.Clin Cancer Res. 2008 Jul 1;14(13):4316-25. doi: 10.1158/1078-0432.CCR-08-0393. Clin Cancer Res. 2008. PMID: 18594015 Free PMC article.
-
Vaccines based on whole recombinant Saccharomyces cerevisiae cells.FEMS Yeast Res. 2010 Dec;10(8):1060-9. doi: 10.1111/j.1567-1364.2010.00665.x. FEMS Yeast Res. 2010. PMID: 20707820 Free PMC article. Review.
-
Randomized, Double-Blind, Placebo-Controlled Phase II Study of Yeast-Brachyury Vaccine (GI-6301) in Combination with Standard-of-Care Radiotherapy in Locally Advanced, Unresectable Chordoma.Oncologist. 2021 May;26(5):e847-e858. doi: 10.1002/onco.13720. Epub 2021 Mar 9. Oncologist. 2021. PMID: 33594772 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources