doi: 10.1006/bbrc.2002.6606.
Solution structure of intracellular signal-transducing peptide derived from human beta(2)-adrenergic receptor
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- PMID: 11883960
- DOI: 10.1006/bbrc.2002.6606
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Solution structure of intracellular signal-transducing peptide derived from human beta(2)-adrenergic receptor
Biochem Biophys Res Commun.
.
Abstract
The structure of intracellular third loop peptide (betaIII-2: RRSSKFCLKEKKALK) was studied by CD and NMR spectroscopy. According to the CD study, this peptide forms a helix in the TFE solution. The three-dimensional molecular structure in TFE was determined by the 2D (1)H NMR spectroscopy. The structure consists of a positive charge cluster on the C-terminal side of the peptide chain. This part will be an active site of the peptide interacting with the G-protein.
(C)2002 Elsevier Science (USA).
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