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Review
. 2002 Apr;4(2):143-51.
doi: 10.1007/s11906-002-0039-9.

Effects of gender on the renin-angiotensin system, blood pressure, and renal function

Amrit K Kang  1 , Judith A Miller
Affiliations
Review

Effects of gender on the renin-angiotensin system, blood pressure, and renal function

Amrit K Kang et al. Curr Hypertens Rep. 2002 Apr.

Abstract

Recent studies have identified key gender differences in cardiovascular function, renal hemodynamics, and the renin-angiotensin system. Extensive epidemiologic evidence has shown a clear gender difference in cardiovascular and renal disease progression, whereby female sex appears to be protective. The mechanisms underlying this phenomenon are unknown, but likely reflect the aforementioned sex differences in common pathophysiologic pathways. This review focuses on studies examining sex differences in these underlying pathways, which together may provide a plausible mechanism for the gender disparity in clinical outcomes.

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