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Review
. 2002 Mar 9;324(7337):588-91.
doi: 10.1136/bmj.324.7337.588.

Science, medicine, and the future: Microdialysis

Markus Müller  1
Affiliations
Review

Science, medicine, and the future: Microdialysis

Markus Müller. BMJ. .
No abstract available

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Figures

Figure 1
Figure 1
Needle type microdialysis probe with a semipermeable membrane at the tip. The probe can be inserted into tissue by means of a guide cannula. The probe's inflow tubing is connected to a microperfusion pump, and the probe is constantly perfused with a physiological solution at a rate of ∼1 μl/min. Samples are continuously collected from the outflow tubing
Figure 2
Figure 2
Diagram of a microdialysis probe. The semipermeable membrane at the probe tip allows exchange of soluble molecules between the probe and the surrounding tissue. When the probe is implanted into tissue interstitium, molecules continuously diffuse out of the interstitial space fluid into the perfusion medium. Samples are continuously collected and analysed by standard chemical analytical techniques
Figure 3
Figure 3
Continuous glucose recording in a patient with type 1 diabetes by means of microdialysis (black line). Capillary blood glucose concentrations (open triangles) were used for comparison. (Reproduced from Jungheim et al with permission of the American Diabetes Association)
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