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Review
. 2002 Apr;76(7):3089-94.
doi: 10.1128/jvi.76.7.3089-3094.2002.

Destiny of unspliced retroviral RNA: ribosome and/or virion?

Melinda Butsch  1 , Kathleen Boris-Lawrie
Affiliations
Review

Destiny of unspliced retroviral RNA: ribosome and/or virion?

Melinda Butsch et al. J Virol. 2002 Apr.
No abstract available

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Figures

FIG. 1.
FIG. 1.
(Model 1) The unspliced genome-length RNA (gray lines with intronic sequences denoted in black) achieves nuclear export and segregates into functionally distinct populations of either mRNA template for translation of viral proteins on host cell ribosomes or genomic RNA that is packaged into assembling virions. (Model 2A) The genome-length RNA can function interchangeably as both mRNA and genomic RNA with no requirement for prior translation. (Model 2B) Prior translation is a requirement for generation of genomic RNA.
See this image and copyright information in PMC

References

    1. Arya, S. K., M. Zamani, and P. Kundra. 1998. Human immunodeficiency virus type 2 lentivirus vectors for gene transfer: expression and potential for helper virus-free packaging. Hum. Gene Ther. 9:1371-1380. - PubMed
    1. Berkowitz, R., J. Fisher, and S. P. Goff. 1996. RNA packaging. Curr. Top. Microbiol. Immunol. 214:177-218. - PubMed
    1. Berlioz, C., and J.-L. Darlix. 1995. An internal ribosomal entry mechanism promotes translation of murine leukemia virus gag polyprotein precursors. J. Virol. 69:2214-2222. - PMC - PubMed
    1. Berlioz, C., C. Torrent, and J.-L. Darlix. 1995. An internal ribosomal entry signal in the rat VL30 region of the Harvey murine sarcoma virus leader and its use in dicistronic retroviral vectors. J. Virol. 69:6400-6407. - PMC - PubMed
    1. Boris-Lawrie, K., T. M. Roberts, and S. Hull. 2001. Retroviral RNA elements integrate components of post-transcriptional gene expression. Life Sci. 69:2697-2709. - PubMed

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