Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Mar 1;294(1):70-4.
doi: 10.1006/viro.2001.1320.

An antibody that prevents the hemagglutinin low pH fusogenic transition

C Barbey-Martin  1 , B Gigant, T Bizebard, L J Calder, S A Wharton, J J Skehel, M Knossow
Affiliations
Free article

An antibody that prevents the hemagglutinin low pH fusogenic transition

C Barbey-Martin et al. Virology. .
Free article

Abstract

We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition.

PubMed Disclaimer

Publication types

MeSH terms

Substances

Associated data

LinkOut - more resources