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. 2002 Jan-Feb;64(1):22-4.

[Expression of the protein marker p16INK4a in the cervix uteri cancer]

[Article in Russian]
G M Volgareva  1 , L E Zavalishina, G A Frank, Iu Iu Andreeva, A N Petrov, F L Kiselev, D D Spitkovskiĭ
Affiliations
  • PMID: 11889694

[Expression of the protein marker p16INK4a in the cervix uteri cancer]

[Article in Russian]
G M Volgareva et al. Arkh Patol. 2002 Jan-Feb.

Abstract

Immunohistochemical study was carried out of 18 cervical carcinomas (13 squamous and 5 adenomatous) and of 3 cases of cervical intraepithelial dysplasia. Formalin-fixed paraffin-embedded tissue samples from biopsies as well as from surgical material were used. Staining was performed with monoclonal antibodies to protein p16INK4a. Cytologic smears of epithelial cervical cells from 7 healthy women were taken as a negative control. The reference group consisted of 5 cancer patients with other tumors (breast cancer, B-cell lymphoma). Overexpression of p16INK4a was registered in cervical cancer.

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