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. 2002 Mar;160(3):755-8.
doi: 10.1016/S0002-9440(10)64896-1.

How many mutations in a cancer?

Ian Tomlinson  1 , Peter Sasieni, Walter Bodmer
Affiliations

How many mutations in a cancer?

Ian Tomlinson et al. Am J Pathol. 2002 Mar.
No abstract available

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Figures

Figure 1.
Figure 1.
Model of cell division, differentiation and death in the colonic cript. F0 represents the stem cell compartment, F1, partly differentiated cells, and F2, fully differentiated cells. Numbers of cells in each compartment are given by N0, N1, N2 and N3. Proportions of cells dying, differentiating, and renewing are given by α1, α2, α3, etc. t0, t1 and t2 represent the times taken for these processes to occur.
See this image and copyright information in PMC

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