Review
doi: 10.1126/stke.2002.123.pe12.
Molecular BKology: the study of splicing and dicing
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- PMID: 11891347
- DOI: 10.1126/stke.2002.123.pe12
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Review
Molecular BKology: the study of splicing and dicing
Sci STKE.
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Abstract
The activity of ion channels is regulated by several different mechanisms. Studies have been undertaken to determine how the large-conductance Ca(2+)-sensitive K(+) channel (the BK channel) is regulated. Fury et al. discuss how the presence or absence of alternatively spliced regions in the BK channel alpha subunit can act as a molecular switch by which different kinases activate the BK channel.
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