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. 2002 Mar;15(3):302-7.
doi: 10.1002/jmri.10061.

Diffusion-weighted MRI in the characterization of soft-tissue tumors

Catherina S P van Rijswijk  1 , Patrik Kunz, Pancras C W Hogendoorn, Antonïe H M Taminiau, Joost Doornbos, Johan L Bloem
Affiliations

Diffusion-weighted MRI in the characterization of soft-tissue tumors

Catherina S P van Rijswijk et al. J Magn Reson Imaging. 2002 Mar.

Abstract

Purpose: To explore the potential of perfusion-corrected diffusion-weighted magnetic resonance imaging (MRI) in characterizing soft-tissue tumors.

Methods and materials: Diffusion-weighted MRI was performed in 23 histologically proven soft-tissue masses using a diffusion-weighted spin-echo sequence with diffusion gradient strengths yielding five b-values (0-701 seconds/mm(2)). True diffusion coefficients and perfusion fractions were estimated and compared with apparent diffusion coefficients (ADCs).

Results: ADC values of all tumors, subcutaneous fat, and muscle were significantly higher than true diffusion coefficients, indicating a contribution of perfusion to the ADC. True diffusion coefficients of malignant tumors (1.08 x 10(-3) mm(2)/second) were significantly lower than those of benign masses (1.71 x 10(-3) mm(2)/second), whereas ADC values between these groups were not significantly different.

Conclusion: Perfusion-corrected diffusion-weighted MRI has potential in differentiating benign from malignant soft-tissue masses.

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