Review
doi: 10.1016/s0092-8674(02)00666-9.
Opioid tolerance-in search of the holy grail
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- PMID: 11893329
- DOI: 10.1016/s0092-8674(02)00666-9
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Review
Opioid tolerance-in search of the holy grail
Cell.
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Free article
Abstract
Tolerance, one of several behavioral adaptations to prolonged opioid treatment, has long been explained by desensitization of opioid receptor signaling and loss of surface receptors. However, recent evidence presents an alternative hypothesis, suggesting that receptor internalization could in fact reduce tolerance in vivo.
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