Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2002 Mar 8;108(5):587-90.
doi: 10.1016/s0092-8674(02)00666-9.

Opioid tolerance-in search of the holy grail

Brigitte L Kieffer  1 , Christopher J Evans
Affiliations
Free article
Review

Opioid tolerance-in search of the holy grail

Brigitte L Kieffer et al. Cell. .
Free article

Abstract

Tolerance, one of several behavioral adaptations to prolonged opioid treatment, has long been explained by desensitization of opioid receptor signaling and loss of surface receptors. However, recent evidence presents an alternative hypothesis, suggesting that receptor internalization could in fact reduce tolerance in vivo.

PubMed Disclaimer

LinkOut - more resources