Review
doi: 10.1016/s0959-437x(02)00290-3.
RNAi: nature abhors a double-strand
Affiliations
- PMID: 11893497
- DOI: 10.1016/s0959-437x(02)00290-3
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Review
RNAi: nature abhors a double-strand
Curr Opin Genet Dev.
2002 Apr.
Abstract
In organisms as diverse as nematodes, trypanosomes, plants, and fungi, double-stranded RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA interference. RNA interference begins with the transformation of the double-stranded RNA into small RNAs that then guide a protein nuclease to destroy their mRNA targets.
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