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Review
. 2002 Apr;12(2):225-32.
doi: 10.1016/s0959-437x(02)00290-3.

RNAi: nature abhors a double-strand

György Hutvágner  1 , Phillip D Zamore
Affiliations
Review

RNAi: nature abhors a double-strand

György Hutvágner et al. Curr Opin Genet Dev. 2002 Apr.

Abstract

In organisms as diverse as nematodes, trypanosomes, plants, and fungi, double-stranded RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA interference. RNA interference begins with the transformation of the double-stranded RNA into small RNAs that then guide a protein nuclease to destroy their mRNA targets.

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