Therapeutic window for nicotinamide following transient focal cerebral ischemia
- PMID: 11893912
- DOI: 10.1097/00001756-200202110-00008
Therapeutic window for nicotinamide following transient focal cerebral ischemia
Abstract
The therapeutic window with the neuroprotectant nicotinamide (NAm) was tested in a model of stroke. Either 2, 4 or 6 h after the onset of transient (2 h) focal cerebral ischemia, Wistar rats received either saline or NAm (500 mg/kg). Sensory and motor behavioral scores and weight of the animals were obtained before surgery, and 2 h, 3 and 7 days after stroke onset. Cerebral infarct volumes were measured on day 7 after sacrifice. NAm given 4 or 6 h after stroke onset significantly (p<0.05) reduced the cerebral infarction and improved the behavioral scores, respectively, compared to saline-injected animals. There was a non-significant improvement in weight gained by NAm-treated rats at 3 and 7 days following stroke compared to the saline-injected controls.
Similar articles
-
Delayed multidose treatment with nicotinamide extends the degree and duration of neuroprotection by reducing infarction and improving behavioral scores up to two weeks following transient focal cerebral ischemia in Wistar rats.Ann N Y Acad Sci. 2001 Jun;939:416-24. doi: 10.1111/j.1749-6632.2001.tb03653.x. Ann N Y Acad Sci. 2001. PMID: 11462797
-
Delayed treatment with nicotinamide (Vitamin B(3)) improves neurological outcome and reduces infarct volume after transient focal cerebral ischemia in Wistar rats.Stroke. 2000 Jul;31(7):1679-85. doi: 10.1161/01.str.31.7.1679. Stroke. 2000. PMID: 10884473
-
Post-treatment with nicotinamide (vitamin B(3)) reduces the infarct volume following permanent focal cerebral ischemia in female Sprague-Dawley and Wistar rats.Neurosci Lett. 2000 Mar 10;281(2-3):111-4. doi: 10.1016/s0304-3940(00)00854-5. Neurosci Lett. 2000. PMID: 10704755
-
The calmodulin antagonist trifluoperazine in transient focal brain ischemia in rats. Anti-ischemic effect and therapeutic window.Stroke. 1997 Dec;28(12):2539-44. doi: 10.1161/01.str.28.12.2539. Stroke. 1997. PMID: 9412646
-
Barbiturate resuscitation from focal cerebral ischemia--A review.Resuscitation. 1981 Jun;9(2):189-96. doi: 10.1016/0300-9572(81)90026-5. Resuscitation. 1981. PMID: 7020025 Review.
Cited by
-
New Therapeutic Concept of NAD Redox Balance for Cisplatin Nephrotoxicity.Biomed Res Int. 2016;2016:4048390. doi: 10.1155/2016/4048390. Epub 2016 Jan 5. Biomed Res Int. 2016. PMID: 26881219 Free PMC article. Review.
-
NAD(+) Metabolism in Age-Related Hearing Loss.Aging Dis. 2014 Apr 1;5(2):150-9. doi: 10.14336/AD.2014.0500150. eCollection 2014 Apr. Aging Dis. 2014. PMID: 24729940 Free PMC article. Review.
-
Mitochondrial dysfunction and NAD(+) metabolism alterations in the pathophysiology of acute brain injury.Transl Stroke Res. 2013 Dec;4(6):618-34. doi: 10.1007/s12975-013-0278-x. Epub 2013 Aug 10. Transl Stroke Res. 2013. PMID: 24323416 Review.
-
Variation in chronic nicotinamide treatment after traumatic brain injury can alter components of functional recovery independent of histological damage.Oxid Med Cell Longev. 2008 Oct-Dec;1(1):46-53. doi: 10.4161/oxim.1.1.6694. Oxid Med Cell Longev. 2008. PMID: 19794908 Free PMC article.
-
Potential roles of HDAC inhibitors in mitigating ischemia-induced brain damage and facilitating endogenous regeneration and recovery.Curr Pharm Des. 2013;19(28):5105-20. doi: 10.2174/1381612811319280009. Curr Pharm Des. 2013. PMID: 23448466 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
