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. 1994:251 Suppl 1:S53-6.
doi: 10.1007/BF02565220.

The effects of ototoxic drugs on mechano-electric transduction channels in chick cochlear hair cells

T Kimitsuki  1 , T Nakagawa, K Hisashi, S Komune, T Uemura
Affiliations

The effects of ototoxic drugs on mechano-electric transduction channels in chick cochlear hair cells

T Kimitsuki et al. Eur Arch Otorhinolaryngol. 1994.

Abstract

The effects of ototoxic drugs on mechano-electrical transduction (MET) currents were investigated in dissociated cochlear hair cells of the chick, using a whole-cell patch-electrode voltage-clamp technique. Dihydrostreptomycin (DHSM) and cisplatin (cis-dichlorodiammine platinum II, CDDP) blocked the MET channel in a dose- and voltage-dependent manner. In contrast, acetyl salicylate did not suppress the MET current. At -50 mV, DHSM and CDDP blocked the MET channel with a Hill coefficient of 0.93 and 2.1, respectively. These findings suggest that a single DHSM molecule or more than one CDDP molecule binds to a single MET channel.

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