Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994:251 Suppl 1:S57-60.
doi: 10.1007/BF02565221.

Voltage-dependent channels in dissociated outer hair cells of the guinea pig

T Nakagawa  1 , S Kakehata, N Akaike, S Komune, T Takasaka, T Uemura
Affiliations

Voltage-dependent channels in dissociated outer hair cells of the guinea pig

T Nakagawa et al. Eur Arch Otorhinolaryngol. 1994.

Abstract

Voltage-dependent channels in outer hair cells (OHCs) dissociated from the guinea pig cochlea were investigated by the use of a whole-cell patch-clamp technique. Two types of K+ current were recorded from OHCs. One was a slowly inactivating K+ current that was activated at a potential more positive than -30 mV. Another is a K+ current that was already activated at resting membrane potential. After suppressing both K+ currents, depolarizing voltage steps elicited a slowly inactivating inward current that was dependent on external Ca2+ and was indicative of an L-type Ca2+ channel in OHCs. Aminoglycoside antibiotics known to be ototoxic selectively inhibited the Ca2+ current.

PubMed Disclaimer

References

    1. J Neurophysiol. 1990 May;63(5):1068-74 - PubMed
    1. Science. 1984 Sep 14;225(4667):1174-5 - PubMed
    1. Science. 1985 Jan 11;227(4683):194-6 - PubMed
    1. J Physiol. 1990 Oct;429:529-51 - PubMed
    1. Brain Res. 1992 May 15;580(1-2):345-7 - PubMed

LinkOut - more resources