Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983;2(1):15-9.
doi: 10.1002/j.1460-2075.1983.tb01373.x.

Evidence for a coupling of synthesis and export of an outer membrane protein in Escherichia coli

M N Hall  1 , J Gabay, M Schwartz
Affiliations

Evidence for a coupling of synthesis and export of an outer membrane protein in Escherichia coli

M N Hall et al. EMBO J. 1983.

Abstract

We describe a lesion, lamB701-708, affecting the hydrophilic portion of the lambda receptor signal sequence. The C to A transversion of the sixth codon of the signal sequence changes a positively charged arginine to a neutral serine. The phenotype conferred by this alteration is unique among previously described signal sequence mutations. The results suggest an essential role for the charged amino acids of the hydrophilic segment in the initial interaction between a nascent secreted protein and a membrane export site. The results further suggest that synthesis of lambda receptor is coupled to its export.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. J Virol. 1972 May;9(5):758-65 - PubMed
    1. Nat New Biol. 1972 Sep 27;239(91):117-20 - PubMed
    1. J Bacteriol. 1973 Dec;116(3):1436-46 - PubMed
    1. Eur J Biochem. 1974 Jul 1;46(1):83-8 - PubMed

Publication types

MeSH terms