Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983;2(2):239-43.
doi: 10.1002/j.1460-2075.1983.tb01412.x.

The beta2-microglobulin mRNA in human Daudi cells has a mutated initiation codon but is still inducible by interferon

F Rosa  1 , H Berissi, J Weissenbach, L Maroteaux, M Fellous, M Revel
Affiliations

The beta2-microglobulin mRNA in human Daudi cells has a mutated initiation codon but is still inducible by interferon

F Rosa et al. EMBO J. 1983.

Abstract

The human Burkitt lymphoma cell line Daudi does not synthesize beta2-microglobulin (beta2m) and lacks the cell surface histocompatibility antigens. The cells, however, contain RNA hybridizing to a cloned human beta2m cDNA probe. cDNA from this Daudi beta2m RNA, was cloned and sequenced. By comparison with cDNA prepared from Ramos cells, which synthesized microglobulin, we determined the sequence of the 20 amino acid long leader peptide of pre-beta2m and show that in Daudi cells the initiator ATG has been mutated to ATC. Although Daudi beta2m RNA cannot be translated, interferon induces the beta2m RNA in Daudi cells as well as in normal human cells.

PubMed Disclaimer

References

    1. Biochem Biophys Res Commun. 1966 Jun 13;23(5):641-6 - PubMed
    1. Nature. 1982 Oct 28;299(5886):833-6 - PubMed
    1. J Bacteriol. 1973 Nov;116(2):1064-6 - PubMed
    1. Biochemistry. 1973 Nov 20;12(24):4811-22 - PubMed
    1. Transplant Rev. 1974;21(0):53-84 - PubMed

Publication types