Granulocyte macrophage-colony stimulating factor and oral mucositis

Abstract

Objective: To evaluate the effect of granulocyte macrophage-colony stimulating factor (GM-CSF) in patients with oral mucositis.

Data sources: Literature was accessed through MEDLINE (1966-June 2000) and bibliographic searches.

Data synthesis: Published literature assessing the use of GM-CSF to treat or prevent oral mucositis was analyzed.

Conclusions: Reports of GM-CSF improving mucositis have been published; however, because of limitations in these reports, insufficient evidence confirms the benefits of GM-CSF. These preliminary studies provide a rationale to conduct well-designed, double-blind, randomized trials to evaluate the safety and efficacy of GM-CSF in the treatment and/or prevention of oral mucositis induced by chemotherapy and/or radiotherapy.